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clyne™
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TREATMENTS → LONGEVITY● NOT WELLNESS. MEDICINE.EVIDENCE-BASED PROTOCOLS · PHYSICIAN-DIRECTED
01 / THE PROTOCOL

Treat aging
like a condition.

BIO-AGE · ILLUSTRATIVE EXAMPLE
−3.4years
Illustrative figure. Actual bio-age outputs depend on your individual panel and protocol; your physician reviews results with you.
WHAT IT IS
Evidence-based, physician-directed protocols: NAD+ injections where indicated, glutathione, low-dose naltrexone, plus FDA-approved cardiovascular and metabolic medications. Every change is reviewed by a physician.
WHAT IT IS NOT
A supplement club. A peptide farm. A VC's cold-plunge podcast. NAD+, glutathione, and LDN are prescribed where clinically indicated, after labs and a real physician conversation.
COST
$109/mo · includes physician review and any FDA-approved prescriptions in-protocol (statin, metformin, SGLT2, etc).
02 / YOUR PANEL

The numbers we move.

ZONES:HIGH-RISKOKOPTIMIZED
APOBOPT
68mg/dL
Δ 90d −24
HS-CRPOPT
0.4mg/L
Δ 90d −0.9
HbA1cOPT
5.1%
Δ 90d −0.3
OMEGA-3OPT
8.2% RBC
Δ 90d +2.1
VO₂ MAXATHLETIC
48ml/kg/min
Δ 90d +5
GRIPOPT
56kg
Δ 90d +4
LP(a)OPT
12nmol/L
Δ 90d =
VIT DOPT
54ng/mL
Δ 90d +9
03 / WHAT WE PRESCRIBE (IF INDICATED)
TIER 1
Rosuvastatin
If APOB > 90.
TIER 1
Metformin
If fasting glu or HOMA-IR elevated.
TIER 2
Empagliflozin
SGLT2, cardiorenal benefit.
TIER 2
Telmisartan
If SBP > 130 + PPAR-γ signal.
TIER 3
NAD+ injections
Where clinically indicated; physician-directed.
* WE PRESCRIBE NAD+, GLUTATHIONE, AND LDN WHERE CLINICALLY INDICATED. ADDITIONAL PEPTIDE THERAPIES ARE COMING, BUT ONLY AS THE EVIDENCE SUPPORTS THEM.
●NAD+ injections (where indicated)●Glutathione injections●Low-dose naltrexone●Metformin protocols●Generic statins from $5/mo●Physician-directed · evidence-based●HIPAA-compliant · no training on your data●NAD+ injections (where indicated)●Glutathione injections●Low-dose naltrexone●Metformin protocols●Generic statins from $5/mo●Physician-directed · evidence-based●HIPAA-compliant · no training on your data●NAD+ injections (where indicated)●Glutathione injections●Low-dose naltrexone●Metformin protocols●Generic statins from $5/mo●Physician-directed · evidence-based●HIPAA-compliant · no training on your data
MEMBER · ANONYMIZED
Member, 0
ILLUSTRATIVE EXAMPLE · 3-year protocol
OUTCOME
Illustrative example. Real outcomes depend on baseline labs, family history, and adherence; your physician reviews each step with you. Individual results vary.
Q1 · BASELINE

The first panel told a different story than the mirror.

I'm 47, I run, I sleep, I eat reasonably. ApoB came back at 112. LP(a) at 86. HOMA-IR borderline. The framework your physician used: this is a 10-year cardiovascular trajectory problem dressed as 'I feel fine.'

ApoB 112 · LP(a) 86 · HOMA-IR 1.9
Q1 · WK 4

Rosuvastatin 5 mg, not 20.

Half the literature says 'start high.' Your physician started low. We talked through risk reduction per ApoB drop, the muscle-soreness data, and titration. Ezetimibe added at week 8 to cut absorption.

rosuva 5 → 10 mg
Q2

ApoB 73. Down 35%.

Lipid panel done at the local Quest. ApoB dropped from 112 to 73. LDL-P down accordingly. LP(a) is genetic and didn't move (we knew it wouldn't). The discussion shifted to 'what's the long-term plan for that LP(a) of 86?'

ApoB 73 · −35%
Q3

Metformin added for HOMA-IR.

Fasting insulin moved the wrong way over 6 months. Your physician added 500 mg ER at dinner. We talked vitamin B12 monitoring (long-term metformin can deplete it) and the cardiovascular signal in the trial data.

metformin 500 mg ER
Q4 · YEAR 1

VO₂ max 42 → 48. Grip 49 → 56 kg.

Bio-age delta from the Horvath panel: −3.4 years. Not a vanity number. It tracks ApoB, hsCRP, HbA1c, and a cluster of inflammation markers that all moved in the same direction.

bio-age −3.4 yrs
YEAR 2

We added empagliflozin.

SGLT2 went on for the cardiorenal data even though I'm not diabetic. Your physician walked through the empagliflozin HFrEF data and the tradeoffs. We evaluated experimental molecules together; the ones without sufficient outcomes data stayed off the protocol.

YEAR 3

ApoB stable. Trend curves intact.

Compounded ApoB lowering buys you a different curve over time. Individual results vary; your physician reviews the data with you at each step.

CAC = 0
04: WHAT IT COSTS

Three tiers. Pick what matches your data appetite.

One subscription. Cancel any time. Follow-ups and Clyne Concierge included.

PROTOCOL
$109/ month
MOST POPULAR
Physician-directed protocol. FDA-approved meds in-protocol.
  • Quarterly physician review
  • Statin / metformin / SGLT2 / antihypertensives included
  • Care team available between visits
  • Pharmacy ships directly to your door
Start Protocol
DEEP DIVE
$1,890/ year
Limited cohort · pricing illustrative
Annual deep workup. Everything in Protocol plus high-touch annual planning.
  • Coronary artery calcium scan review (your imaging)
  • DNA methylation clock (when available)
  • 60-min annual planning call
  • Compounded options on request
Join the waitlist
06: WHO PRESCRIBES

Real doctors. Not a chatbot in a lab coat.

Every prescription is signed by a physician licensed in your state. They review your intake, medical history, and goals before making the call.

Your physician
Licensed in your state, board-certified

Your physician is licensed in your state, board-certified, and reviews every case personally.

50 STATE LIC.
06: EVIDENCE

Receipts. Cited.

01
Lifetime ApoB exposure and CVD risk (Mendelian randomization)
Each 10 mg/dL lower lifetime ApoB associated with 22% lower CHD risk. Earlier intervention compounds.
02
Metformin in non-diabetic primary prevention (TAME framework)
Largest RCT of metformin in healthy aging adults; design and rationale paper. Best evidence to date is observational; we treat that honestly.
03
Empagliflozin in HFpEF, non-diabetic adults
21% reduction in cardiovascular death or hospitalization. Effect independent of glycemic status.
04
Lp(a) elevation and CVD risk: clinical management
Lp(a) > 50 mg/dL doubles ASCVD risk. PCSK9 inhibitors reduce by ~25%. New therapies (pelacarsen, olpasiran) in phase 3.
05
VO₂ max as a mortality predictor
Each 1 MET (3.5 ml/kg/min) increase associated with lower all-cause mortality in observational cohorts.
06
DNA methylation age of human tissues and cell types
Horvath's epigenetic clock derived from CpG methylation patterns; subsequent cohorts have linked accelerated DNAm age to all-cause mortality.
07: WHEN WE WON'T PRESCRIBE

The drugs we won't sell.

Longevity is the field most likely to be cargo-cult medicine. Here's where we draw the line.

You want supplements branded as 'longevity stack'
We prescribe FDA-approved medications and a small set of compounded formulas with evidence. We don't ship branded supplements.
You want testosterone for 'performance'
TRT is a treatment for measured hypogonadism, not a longevity drug. We won't prescribe outside indication.
You want unapproved peptides today
Additional peptide therapies are coming, but only as the evidence supports them. We won't prescribe what isn't ready.
You're asking for someone else
Every member is reviewed individually. We don't process surrogate intakes for spouses, parents, or executives.
Acute illness or hospitalization in the last 90 days
Bloodwork is unreliable during recovery. We re-baseline first.
08: FREQUENTLY ASKED

The questions we hear most. Answered in plain terms.

When you upload labs from your PCP, Quest, or LabCorp, your physician reviews the full picture: standard CMP and CBC, advanced lipids (ApoB, LP(a), Lp-PLA2, oxLDL), inflammation (hsCRP, IL-6, fibrinogen), insulin axis (fasting insulin, HOMA-IR, HbA1c), thyroid (TSH, free T3, free T4, antibodies), nutrient status (B12, folate, vitamin D, omega-3 RBC), hormones (testosterone, SHBG, DHEA-S, estradiol, cortisol), liver/kidney function, urate, and ferritin. You get a written interpretation back.

FDA-approved cardiovascular and metabolic drugs in evidence-backed protocols: rosuvastatin, atorvastatin, ezetimibe, bempedoic acid, metformin, empagliflozin, dapagliflozin, telmisartan, low-dose aspirin (when indicated). We also prescribe NAD+ injections, glutathione, and low-dose naltrexone where clinically indicated. PCSK9 inhibitors via specialty pharmacy when LP(a) or refractory ApoB warrants.

No. We do not sell supplements. We will tell you which of yours have evidence (omega-3, vitamin D if low, magnesium glycinate for sleep) and which don't (most of them). Our compensation is the subscription, not affiliate commissions on capsules.

Most members keep their PCP. We send a written summary after every quarterly review, addressed to whomever they want (including the PCP). We coordinate on prescriptions to avoid duplication and we never modify a med your PCP started without that loop.

If you've run a methylation clock through TruDiagnostic, GrimAge, or similar, your Deep Dive review interprets it alongside the rest of your panel. They're useful for trend over years, less useful for quarter-to-quarter. We treat them as one input, not the headline metric.

Generally no; we're a cash-pay subscription. The labs themselves are sometimes reimbursable through HSA/FSA, and the prescriptions are written generic so most cost $5–25/month at retail pharmacy.

Cautious and individualized. The evidence is uneven. Your physician helps you design N-of-1 experiments around the data you can already track yourself (sleep, weight, HRV from a wearable, panels you bring from your PCP) so you can see the signal in your own data, not just the influencer's.

Yes. Clyne Concierge interprets uploaded lab PDFs and your physician double-checks the read. You don't have to switch lab providers to get value.

Most programs are lab-and-recommendations services. We add a physician licensed in your state who can actually prescribe, plus an opinionated point of view on what to do with each marker. Those are great starting points; we're a longer-term care arrangement.

Then we change the protocol. Most plateaus are dose, adherence, or root-cause issues we missed. Your physician owns the iteration loop, not you.

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09: START THE PROTOCOL

A physician-led plan for the next thirty years.

A physician licensed in your state designs your protocol, prescribes the FDA-approved meds that fit, and reviews your progress quarterly. When you bring labs from your PCP or Quest, your physician interprets every marker and adjusts the plan accordingly.

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