What this is
Extended-release metformin at longevity dosing (500mg). The most widely studied anti-aging medication, used off-label for metabolic optimization and cellular health.
Active ingredient
Metformin HCl ER · 500MG ER · Tablet
Ingredients & key features
- Most widely studied anti-aging medication
- Off-label for metabolic optimization
- Extended-release 500mg
- Cellular health support
Why members choose it
- Free expedited shipping.
- No hidden fees. Cancel anytime.
- Doctor-led plans and ongoing support.
- Prescription-based when appropriate, safe and regulated.
- Science-backed options matched to your goals.
Common questions
Before you start.
The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Included with your Clyne membership
You're joining a program, not just filling a prescription.
Physician + RxFree 2-day shippingClyne ConciergeDose trackingDietitian consults
See everything included Clyne Concierge
Ask Clyne Concierge about thisQuestions about Metformin ER (Longevity Protocol)?
Clyne Concierge translates the clinical details (dosing, timing, interactions) into plain English. Ask anything before you start.
More options
Medication made affordable
Without the need for insurance
Scroll or use arrows to browse · Auto-scrolls slowly (pauses when you hover)
Clyne connects members with licensed providers who may prescribe medication through state-licensed pharmacies. Prescription medication only available if prescribed after an online consultation with a healthcare provider. Physicians may prescribe compounded medications as needed to meet member needs or drug shortages. The FDA does not review or approve any compounded medications for safety or effectiveness. Results may vary. Plans are offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
Apply online and meet with a provider
Step1
Share your health goals and history with a licensed provider. They’ll help determine if a longevity-focused plan is right for you.
Receive your regimen at home
Step2
If you qualify, your personalized plan (whether supplements, peptides, or other treatments) is shipped to your door.
Track progress with support
Step3
Get on-demand support from your care team when you need it.
The experience
Start your longevity journey today
- One-on-one guidance from US-based health experts
- Science-backed, provider-prescribed options
- Ongoing support and follow-ups
Questions
Frequently asked questions about longevity
What’s included in my plan?
Your plan includes a personalized regimen (as prescribed), access to your provider, and support. Delivery and follow-ups are part of the experience.
How do longevity treatments work?
Longevity-focused treatments may include supplements, peptides, or other options that support cellular health, energy, and recovery. Your provider will recommend a plan based on your goals and health profile.
Can I cancel anytime?
Yes. You can cancel your subscription at any time. No long-term contracts or cancellation fees.
When will I notice a difference?
Results vary. Some people notice changes in energy or well-being within weeks; others over several months. Your provider can set realistic expectations for your plan.
Can my provider adjust my plan?
Yes. Your provider can update your regimen based on your progress and goals.
Important Safety Information
For Metformin ER (Longevity Protocol) (Metformin (biguanide))
Boxed Warning
Lactic acidosis (rare but potentially fatal). Risk increases with renal impairment, dehydration, sepsis, hypoxic states, excessive alcohol intake, hepatic impairment, and acute heart failure. Stop metformin and contact your physician if you develop malaise, muscle pain, breathing difficulty, sleepiness, or abdominal pain.
Pricing
Longevity treatment options
Starts at $25 / month
- No hidden fees
- Personalized plans
- Provider support
- Fast shipping
Price shown is the published manufacturer or self-pay rate. Actual price may depend on insurance, manufacturer copay programs, and the plan your physician prescribes.
Disclaimer
Only available if prescribed after an online consultation with a healthcare provider. Benefits outlined are based on third-party studies. Plans are offered as a subscription service which can be canceled at any time. Actual product packaging may appear differently than shown. The statements on this page have not been evaluated by the FDA. Results may vary. If you notice any side effects while using this treatment, contact your healthcare provider immediately.