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Understanding Male Pattern Baldness: Causes and Treatment Options

85% of men experience thinning by age 50. Here's the science behind genetic hair loss and what actually works.

C

Clyne Health

March 12, 2026

Hair LossDHTTreatment
Understanding Male Pattern Baldness: Causes and Treatment Options

What Causes Male Pattern Baldness?

Androgenetic alopecia is driven by dihydrotestosterone (DHT), a hormone derived from testosterone via the enzyme 5-alpha reductase. In genetically susceptible men, DHT binds to receptors in scalp hair follicles, causing them to miniaturize — producing progressively thinner, shorter hairs until they stop growing entirely.

The Norwood Scale

Hair loss severity is measured on the Norwood scale (I-VII). Type I shows no significant hair loss. Type II-III shows recession at the temples. Type IV-V shows significant thinning at the crown. Type VI-VII represents advanced baldness. Treatment is most effective at stages II-IV.

FDA-Approved Treatments

Finasteride (oral, 1mg daily) blocks DHT production by ~70%. Minoxidil (topical, 5%) stimulates blood flow to follicles and extends the growth phase. Used together, they produce superior results — 94% improvement at 12 months versus 80% (finasteride alone) or 59% (minoxidil alone).

Emerging Options

Topical finasteride offers lower systemic absorption with comparable scalp DHT reduction. Low-level laser therapy (LLLT) shows modest benefit as an adjunct treatment. Platelet-rich plasma (PRP) injections have promising but inconsistent evidence.

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Editorial standards

This content is reviewed by Clyne®'s editorial team and grounded in published clinical evidence. Citations are listed at the end of each piece. Clyne® Concierge translates the science; your physician makes all clinical decisions. We never fabricate trial data, patient stories, or outcomes.

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