NAD+ is a coenzyme essential for energy production, DNA repair, and sirtuin activation. NAD+ levels decline approximately 50% between ages 20 and 50, linked to age-related disease.
What NAD+ Does
NAD+ serves as a critical cofactor in mitochondrial energy production, DNA repair via PARP enzymes, sirtuin activation which regulates inflammation and metabolism, and circadian rhythm regulation.
The Evidence
Preclinical studies show NAD+ repletion reversed age-related tissue decline and extended healthy lifespan. A 2024 human trial showed improved walking speed, grip strength, and cognitive scores in adults over 60.
Delivery Methods
Injectable NAD+ bypasses digestive breakdown, ensuring near-100% bioavailability. Results typically appear within 1-2 weeks. Oral supplements have significantly lower bioavailability.
What Clyne Offers
Clyne provides medically supervised NAD+ therapy through subcutaneous injections, nasal spray, and topical cream formulations with provider monitoring.
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This content is reviewed by Clyne®'s editorial team and grounded in published clinical evidence. Citations are listed at the end of each piece. Clyne® Concierge translates the science; your physician makes all clinical decisions. We never fabricate trial data, patient stories, or outcomes.
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